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Faculty Rank: Professor
Medical or Graduate Education:
Tehran University School of Medical Sciences, Iran
Guy's Hospital, England - Internal Medicine
Hillingdon Hospital, England - Gastroenterology
Royal Postgraduate Medical School, England - Gastroenterology
University of Maryland Medical Center - Gastroenterology
Inflammatory bowel disease
Irritable bowel syndrome
Leaky gut syndrome
Liver disease, alcoholic
Gastrointestinal motility disorders
Effect of alcohol on esophageal motility and intestinal function
Inflammatory bowel disease
Permeation of the intestinal barrier in gastrointestinal disease
Oxygen free radicals in gastrointestinal disease
Below is a list of scientific publications for which this practitioner was either the primary author or a contributor. Citations come from PubMed, a database of biomedical literature, life science journals and online books. PubMed is a service of the US Library of Medicine at the National Institutes of Health. Click on the title of the cited work for more information (this will take you directly to PubMed.gov). Listings go back five years.
CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis. Abdelmegeed MA, Banerjee A, Jang S, Yoo SH, Yun JW, Gonzalez FJ, Keshavarzian A, Song BJ Free Radic. Biol. Med. 2013 Sep 21 65C:1238-1245. Impact of dietary fiber fermentation from cereal grains on metabolite production by the fecal microbiota from normal weight and obese individuals. Yang J, Keshavarzian A, Rose DJ J Med Food 2013 Sep 16(9):862-7. A Role for TLR Signaling During B Cell Activation in Antiretroviral-Treated HIV Individuals. Siewe B, Keshavarzian A, French A, Demarais P, Landay A AIDS Res. Hum. Retroviruses 2013 Oct 29(10):1353-60. In vitro characterization of the impact of selected dietary fibers on fecal microbiota composition and short chain fatty acid production. Yang J, Martínez I, Walter J, Keshavarzian A, Rose DJ Anaerobe 2013 Oct 23:74-81. Diagnostic Medical Radiation in Inflammatory Bowel Disease: How to Limit Risk and Maximize Benefit. Swanson G, Behara R, Braun R, Keshavarzian A. Inflamm Bowel Dis. 2013 2013 Jun 20. [Epub ahead of print] Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability. Forsyth CB, Voigt RM, Shaikh M, Tang Y, Cederbaum AI, Turek FW, Keshavarzian A Am. J. Physiol. Gastrointest. Liver Physiol. 2013 Jul 15 305(2):G185-95. Ethanol-induced mast cell-mediated inflammation leads to increased susceptibility of intestinal tumorigenesis in the APC ?468 min mouse model of colon cancer. Wimberly AL, Forsyth CB, Khan MW, Pemberton A, Khazaie K, Keshavarzian A. Alcohol Clin Exp Res. 2013 2013 Jan 37 Suppl 1:E199-208. doi: 10.1111/j.1530-0277.2012.01894.x. Regulatory B cell frequency correlates with markers of HIV disease progression and attenuates anti-HIV CD8+ T cell function in vitro. Siewe B, Stapleton JT, Martinson J, Keshavarzian A, Kazmi N, Demarais PM, French AL, Landay A. J Leukoc Biol. 2013 2013 Feb 22. [Epub ahead of print] PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer. Khan MW, Keshavarzian A, Gounaris E, Melson JE, Cheon EC, Blatner NR, Chen ZE, Tsai FN, Lee G, Ryu H, Barrett TA, Bentrem DJ, Beckhove P, Khazaie K. Clin Cancer Res. 2013 2013 Apr 12. [Epub ahead of print] Investing in academic medicine research mentoring: low cost, high return. Skarupski KA, Keshavarzian A. Gastroenterology. 2013 2013 Apr 144(4):e21-2. doi: 10.1053/j.gastro.2013.01.064. Epub 2013 Feb 24. No abstract available. Chronic alcohol exposure renders epithelial cells vulnerable to bacterial infection. Wood S, Pithadia R, Rehman T, Zhang L, Plichta J, Radek KA, Forsyth C, Keshavarzian A, Shafikhani SH. PLoS One. 2013 2013 8(1):e54646. doi: 10.1371/journal.pone.0054646. Epub 2013 Jan 24. Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation. Summa KC, Voigt RM, Forsyth CB, Shaikh M, Cavanaugh K, Tang Y, Vitaterna MH, Song S, Turek FW, Keshavarzian A PLoS ONE 2013 8(6):e67102. Inpatient capsule endoscopy leads to frequent incomplete small bowel examinations. Yazici C, Losurdo J, Brown MD, Oosterveen S, Rahimi R, Keshavarzian A, Bozorgnia L, Mutlu E. World J Gastroenterol. 2012 2012 Sep 28 18(36):5051-7. doi: 10.3748/wjg.v18.i36.5051. Colonic microbiome is altered in alcoholism. Mutlu EA, Gillevet PM, Rangwala H, Sikaroodi M, Naqvi A, Engen PA, Kwasny M, Lau CK, Keshavarzian A. Am J Physiol Gastrointest Liver Physiol. 2012 2012 May 1 302(9):G966-78. doi: 10.1152/ajpgi.00380.2011. Epub 2012 Jan 12. Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases. Shannon KM, Keshavarzian A, Dodiya HB, Jakate S, Kordower JH. Mov Disord. 2012 2012 May 27(6):716-9. doi: 10.1002/mds.25020. Epub 2012 May 1. Addressing the mind, body, and spirit in a gastrointestinal practice for inflammatory bowel disease patients. Jedel S, Hankin V, Voigt RM, Keshavarzian A. Clin Gastroenterol Hepatol. 2012 2012 Mar 10(3):244-6. doi: 10.1016/j.cgh.2011.11.028. Epub 2011 Dec 13. No abstract available. Unusual thrombotic complications. Broucek JR, Francescatti AB, Swanson GR, Keshavarzian A, Brand MI, Saclarides TJ. Am Surg. 2012 2012 Jun 78(6):728-9. No abstract available. Lymphogranuloma venereum proctosigmoiditis is a mimicker of inflammatory bowel disease. Gallegos M, Bradly D, Jakate S, Keshavarzian A. World J Gastroenterol. 2012 2012 Jul 7 18(25):3317-21. doi: 10.3748/wjg.v18.i25.3317. Role of Snail activation in alcohol-induced iNOS-mediated disruption of intestinal epithelial cell permeability. Forsyth CB, Tang Y, Shaikh M, Zhang L, Keshavarzian A. Alcohol Clin Exp Res. 2011 Sep 35(9):1635-43 doi: 10.1111/j.1530-0277.2011.01510.x New molecular insights into inflammatory bowel disease-induced diarrhea. Tang Y, Forsyth CB, Keshavarzian A. Expert Rev Gastroenterol Hepatol. 2011 Oct 5(5):615-25. Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice. Mutlu EA, Engen PA, Soberanes S, Urich D, Forsyth CB, Nigdelioglu R, Chiarella SE, Radigan KA, Gonzalez A, Jakate S, Keshavarzian A, Budinger GR, Mutlu GM. Part Fibre Toxicol. 2011 Jun 9 8:19. Cap polyposis with protein-losing enteropathy. Gallegos M, Lau C, Bradly DP, Blanco L, Keshavarzian A, Jakate SM. Gastroenterol Hepatol (N Y). 2011 Jun 7(6):415-20 Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease. Shannon KM, Keshavarzian A, Mutlu E, Dodiya HB, Daian D, Jaglin JA, Kordower JH. Mov Disord. 2011 Jul 15 doi: 10.1002/mds.23838 Role of intestinal circadian genes in alcohol-induced gut leakiness. Swanson G, Forsyth CB, Tang Y, Shaikh M, Zhang L, Turek FW, Keshavarzian A. Alcohol Clin Exp Res. 2011 Jul 35(7):1305-14. doi: 10.1111/j.1530-0277.2011.01466.x The role of oral hygiene in inflammatory bowel disease Singhal S, Dian D, Keshavarzian A, Fogg L, Fields JZ, Farhadi A Dig Dis Sci 2011 Jan 56(1):170-5 Sleep disturbances and inflammatory bowel disease: a potential trigger for disease flare? Swanson GR, Burgess HJ, Keshavarzian A Expert Rev Clin Immunol 2011 Jan 7(1):29-36 Is Moderate Red Wine Consumption Safe in Inactive Inflammatory Bowel Disease? Swanson GR, Tieu V, Shaikh M, Forsyth C, Keshavarzian A. Digestion. 2011 Aug 26 84(3):238-244 Solid-phase microextraction and the human fecal VOC metabolome. Dixon E, Clubb C, Pittman S, Ammann L, Rasheed Z, Kazmi N, Keshavarzian A, Gillevet P, Rangwala H, Couch RD. PLoS One. 2011 Apr 8 6(4):e18471. Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease. Forsyth CB, Shannon KM, Kordower JH, Voigt RM, Shaikh M, Jaglin JA, Estes JD, Dodiya HB, Keshavarzian A. PLoS One. 2011 6(12):e28032 Histopathology predictors of medically refractory ulcerative colitis Melson JE, Giusto D, Kwasny M, Eichenseer P, Jakate S, Keshavarzian A Dis Colon Rectum 2010 Sep 53(9):1280-6 Apoptosis and inflammation: role of adipokines in inflammatory bowel disease. Ponemone V, Keshavarzian A, Brand MI, Saclarides T, Abcarian H, Cabay RJ, Fletcher E, Larsen B, Durstine LJ, Fantuzzi G, Fayad R. Clin Transl Gastroenterol. 2010 2010 Oct 21 1:e1. doi: 10.1038/ctg.2010.1. Pattern of alcohol consumption and its effect on gastrointestinal symptoms in inflammatory bowel disease Swanson GR, Sedghi S, Farhadi A, Keshavarzian A Alcohol 2010 May 44(3):223-8 Network-based modeling of the human gut microbiome Naqvi A, Rangwala H, Keshavarzian A, Gillevet P Chem Biodivers 2010 May 7(5):1040-50 Quantitative assessment of the human gut microbiome using multitag pyrosequencing Gillevet P, Sikaroodi M, Keshavarzian A, Mutlu EA Chem Biodivers 2010 May 7(5):1065-75 Starch-entrapped microspheres show a beneficial fermentation profile and decrease in potentially harmful bacteria during in vitro fermentation in faecal microbiota obtained from patients with inflammatory bowel disease Rose DJ, Venema K, Keshavarzian A, Hamaker BR Br J Nutr 2010 May 103(10):1514-24 The Role of Matrix Metalloproteinases in Intestinal Epithelial Wound Healing During Normal and Inflammatory States Hayden DM, Forsyth C, Keshavarzian A J Surg Res 2010 Mar 26 Endogenous melatonin profiles in asymptomatic inflammatory bowel disease Burgess HJ, Swanson GR, Keshavarzian A Scand J Gastroenterol 2010 Jun 45(6):759-61 Alcohol stimulates activation of Snail, epidermal growth factor receptor signaling, and biomarkers of epithelial-mesenchymal transition in colon and breast cancer cells Forsyth CB, Tang Y, Shaikh M, Zhang L, Keshavarzian A Alcohol Clin Exp Res 2010 Jan 34(1):19-31 Current Therapeutic Approaches in Inflammatory Bowel Disease Sohrabpour AA, Malekzadeh R, Keshavarzian A Curr Pharm Des 2010 Dec 3 Effects of aspirin on gastroduodenal permeability in alcoholics and controls Farhadi A, Keshavarzian A, Kwasny MJ, Shaikh M, Fogg L, Lau C, Fields JZ, Forsyth CB Alcohol 2010 Aug 44(5):447-56 Laparoscopic transgastric esophageal mucosal resection: 4-year minimum follow-up Frantzides CT, Carlson MA, Keshavarzian A, Roberts JE Am J Surg 2010 Aug 200(2):305-7 MicroRNAs: master regulators of ethanol abuse and toxicity? Miranda RC, Pietrzykowski AZ, Tang Y, Sathyan P, Mayfield D, Keshavarzian A, Sampson W, Hereld D Alcohol Clin Exp Res 2010 Apr 34(4):575-87 Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats Mutlu E, Keshavarzian A, Engen P, Forsyth CB, Sikaroodi M, Gillevet P Alcohol Clin Exp Res 2009 Oct 33(10):1836-46 Starch-entrapped microspheres extend in vitro fecal fermentation, increase butyrate production, and influence microbiota pattern Rose DJ, Keshavarzian A, Patterson JA, Venkatachalam M, Gillevet P, Hamaker BR Mol Nutr Food Res 2009 May 53 Suppl 1:S121-30 SIMDOT-AbMe: microphysiologically based simulation tool for quantitative prediction of systemic and local bioavailability of targeted oral delivery formulations Haddish-Berhane N, Farhadi A, Nyquist C, Haghighi K, Keshavarzian A Drug Metab Dispos 2009 Mar 37(3):608-18 Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis Forsyth CB, Farhadi A, Jakate SM, Tang Y, Shaikh M, Keshavarzian A Alcohol 2009 Mar 43(2):163-72 Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats Keshavarzian A, Farhadi A, Forsyth CB, Rangan J, Jakate S, Shaikh M, Banan A, Fields JZ J Hepatol 2009 Mar 50(3):538-47 Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis Tang Y, Preuss F, Turek FW, Jakate S, Keshavarzian A Sleep Med 2009 Jun 10(6):597-603 Oats supplementation prevents alcohol-induced gut leakiness in rats by preventing alcohol-induced oxidative tissue damage Tang Y, Forsyth CB, Banan A, Fields JZ, Keshavarzian A J Pharmacol Exp Ther 2009 Jun 329(3):952-8 Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage Tang Y, Forsyth CB, Farhadi A, Rangan J, Jakate S, Shaikh M, Banan A, Fields JZ, Keshavarzian A Alcohol Clin Exp Res 2009 Jul 33(7):1220-30 Reconsidering the methodology of "stress" research in inflammatory bowel disease Keefer L, Keshavarzian A, Mutlu E J Crohns Colitis 2008 Sep 2(3):193-201 Atopic irritable bowel syndrome: a novel subgroup of irritable bowel syndrome with allergic manifestations Tobin MC, Moparty B, Farhadi A, DeMeo MT, Bansal PJ, Keshavarzian A Ann Allergy Asthma Immunol 2008 Jan 100(1):49-53 Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease Tang Y, Banan A, Forsyth CB, Fields JZ, Lau CK, Zhang LJ, Keshavarzian A Alcohol Clin Exp Res 2008 Feb 32(2):355-64 Adverse effects of chronic circadian desynchronization in animals in a "challenging" environment Preuss F, Tang Y, Laposky AD, Arble D, Keshavarzian A, Turek FW Am J Physiol Regul Integr Comp Physiol 2008 Dec 295(6):R2034-40 Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis Farhadi A, Gundlapalli S, Shaikh M, Frantzides C, Harrell L, Kwasny MM, Keshavarzian A Liver Int 2008 Aug 28(7):1026-33 Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium Purohit V, Bode JC, Bode C, Brenner DA, Choudhry MA, Hamilton F, Kang YJ, Keshavarzian A, Rao R, Sartor RB, Swanson C, Turner JR Alcohol 2008 Aug 42(5):349-61
To watch a brief video of Ali Keshavarzian, MD, click the play button at the lower left corner of the video frame below.
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GI [gastrointestinal] symptoms is the type of symptoms that are not socially comfortable. It’s not the chest pain that you can talk about it in the parties. It’s not your high blood pressure or cholesterol. You’re talking about diarrhea. You’re talking about urgency. That is not a topic of conversation. And acknowledging that difficulty and loneliness associated with symptoms associated with GI disease, typically put patient at ease and make the conversation much easier to move forward.
Through my practice I obviously take care of patients that they require my immediate attention because they are ill at the present time. They have diseases that requires to be taken care of. And my research will help those that they become ill five years, ten years, and 20 years down the road.