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Ali Keshavarzian, MD

Ali Keshavarzian, MD
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Specialty:
  • Gastroenterology
  • Internal Medicine
Board Certification:
  • Gastroenterology
  • Internal Medicine
Faculty Rank: Professor
Medical or Graduate Education: Tehran University School of Medical Sciences, Iran
Residency: Guy's Hospital, England - Internal Medicine
  Hillingdon Hospital, England - Gastroenterology
Fellowship: Royal Postgraduate Medical School, England - Gastroenterology
  University of Maryland Medical Center - Gastroenterology
Clinical Expertise:
  • Capsule endoscopy
  • Colonoscopy
  • Crohn's disease
  • Esophagogastroduodenoscopy
  • Inflammatory bowel disease
  • Irritable bowel syndrome
  • Leaky gut syndrome
  • Liver disease, alcoholic
  • Ulcerative colitis
Research Interests:
  • Gastrointestinal motility disorders
  • Effect of alcohol on esophageal motility and intestinal function
  • Inflammatory bowel disease
  • Permeation of the intestinal barrier in gastrointestinal disease
  • Oxygen free radicals in gastrointestinal disease
Languages Spoken:
  • Farsi
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  • University Gastroenterologists
  • Professional Building
  • 1725 W. Harrison St.
  • Suite 207
  • Chicago, IL  60612
  • Phone: (312) 942-5861
  • Fax: (312) 563-3945
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Below is a list of scientific publications for which this practitioner was either the primary author or a contributor. Citations come from PubMed, a database of biomedical literature, life science journals and online books. PubMed is a service of the US Library of Medicine at the National Institutes of Health. Click on the title of the cited work for more information (this will take you directly to PubMed.gov). Listings go back five years.

  1. CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis.
    Abdelmegeed MA, Banerjee A, Jang S, Yoo SH, Yun JW, Gonzalez FJ, Keshavarzian A, Song BJ
    Free Radic. Biol. Med.
    2013 Sep 21
    65C:1238-1245.
  2. Impact of dietary fiber fermentation from cereal grains on metabolite production by the fecal microbiota from normal weight and obese individuals.
    Yang J, Keshavarzian A, Rose DJ
    J Med Food
    2013 Sep
    16(9):862-7.
  3. A Role for TLR Signaling During B Cell Activation in Antiretroviral-Treated HIV Individuals.
    Siewe B, Keshavarzian A, French A, Demarais P, Landay A
    AIDS Res. Hum. Retroviruses
    2013 Oct
    29(10):1353-60.
  4. In vitro characterization of the impact of selected dietary fibers on fecal microbiota composition and short chain fatty acid production.
    Yang J, Martínez I, Walter J, Keshavarzian A, Rose DJ
    Anaerobe
    2013 Oct
    23:74-81.
  5. Diagnostic Medical Radiation in Inflammatory Bowel Disease: How to Limit Risk and Maximize Benefit.
    Swanson G, Behara R, Braun R, Keshavarzian A.
    Inflamm Bowel Dis. 2013
    2013 Jun 20. [Epub ahead of print]
  6. Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability.
    Forsyth CB, Voigt RM, Shaikh M, Tang Y, Cederbaum AI, Turek FW, Keshavarzian A
    Am. J. Physiol. Gastrointest. Liver Physiol.
    2013 Jul 15
    305(2):G185-95.
  7. Ethanol-induced mast cell-mediated inflammation leads to increased susceptibility of intestinal tumorigenesis in the APC ?468 min mouse model of colon cancer.
    Wimberly AL, Forsyth CB, Khan MW, Pemberton A, Khazaie K, Keshavarzian A.
    Alcohol Clin Exp Res. 2013
    2013 Jan
    37 Suppl 1:E199-208. doi: 10.1111/j.1530-0277.2012.01894.x.
  8. Regulatory B cell frequency correlates with markers of HIV disease progression and attenuates anti-HIV CD8+ T cell function in vitro.
    Siewe B, Stapleton JT, Martinson J, Keshavarzian A, Kazmi N, Demarais PM, French AL, Landay A.
    J Leukoc Biol. 2013
    2013 Feb 22. [Epub ahead of print]
  9. PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer.
    Khan MW, Keshavarzian A, Gounaris E, Melson JE, Cheon EC, Blatner NR, Chen ZE, Tsai FN, Lee G, Ryu H, Barrett TA, Bentrem DJ, Beckhove P, Khazaie K.
    Clin Cancer Res. 2013
    2013 Apr 12. [Epub ahead of print]
  10. Investing in academic medicine research mentoring: low cost, high return.
    Skarupski KA, Keshavarzian A.
    Gastroenterology. 2013
    2013 Apr
    144(4):e21-2. doi: 10.1053/j.gastro.2013.01.064. Epub 2013 Feb 24. No abstract available.
  11. Chronic alcohol exposure renders epithelial cells vulnerable to bacterial infection.
    Wood S, Pithadia R, Rehman T, Zhang L, Plichta J, Radek KA, Forsyth C, Keshavarzian A, Shafikhani SH.
    PLoS One. 2013
    2013
    8(1):e54646. doi: 10.1371/journal.pone.0054646. Epub 2013 Jan 24.
  12. Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation.
    Summa KC, Voigt RM, Forsyth CB, Shaikh M, Cavanaugh K, Tang Y, Vitaterna MH, Song S, Turek FW, Keshavarzian A
    PLoS ONE
    2013
    8(6):e67102.
  13. Inpatient capsule endoscopy leads to frequent incomplete small bowel examinations.
    Yazici C, Losurdo J, Brown MD, Oosterveen S, Rahimi R, Keshavarzian A, Bozorgnia L, Mutlu E.
    World J Gastroenterol. 2012
    2012 Sep 28
    18(36):5051-7. doi: 10.3748/wjg.v18.i36.5051.
  14. Colonic microbiome is altered in alcoholism.
    Mutlu EA, Gillevet PM, Rangwala H, Sikaroodi M, Naqvi A, Engen PA, Kwasny M, Lau CK, Keshavarzian A.
    Am J Physiol Gastrointest Liver Physiol. 2012
    2012 May 1
    302(9):G966-78. doi: 10.1152/ajpgi.00380.2011. Epub 2012 Jan 12.
  15. Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases.
    Shannon KM, Keshavarzian A, Dodiya HB, Jakate S, Kordower JH.
    Mov Disord. 2012
    2012 May
    27(6):716-9. doi: 10.1002/mds.25020. Epub 2012 May 1.
  16. Addressing the mind, body, and spirit in a gastrointestinal practice for inflammatory bowel disease patients.
    Jedel S, Hankin V, Voigt RM, Keshavarzian A.
    Clin Gastroenterol Hepatol. 2012
    2012 Mar
    10(3):244-6. doi: 10.1016/j.cgh.2011.11.028. Epub 2011 Dec 13. No abstract available.
  17. Unusual thrombotic complications.
    Broucek JR, Francescatti AB, Swanson GR, Keshavarzian A, Brand MI, Saclarides TJ.
    Am Surg. 2012
    2012 Jun
    78(6):728-9. No abstract available.
  18. Lymphogranuloma venereum proctosigmoiditis is a mimicker of inflammatory bowel disease.
    Gallegos M, Bradly D, Jakate S, Keshavarzian A.
    World J Gastroenterol. 2012
    2012 Jul 7
    18(25):3317-21. doi: 10.3748/wjg.v18.i25.3317.
  19. Role of Snail activation in alcohol-induced iNOS-mediated disruption of intestinal epithelial cell permeability.
    Forsyth CB, Tang Y, Shaikh M, Zhang L, Keshavarzian A.
    Alcohol Clin Exp Res.
    2011 Sep
    35(9):1635-43 doi: 10.1111/j.1530-0277.2011.01510.x
  20. New molecular insights into inflammatory bowel disease-induced diarrhea.
    Tang Y, Forsyth CB, Keshavarzian A.
    Expert Rev Gastroenterol Hepatol.
    2011 Oct
    5(5):615-25.
  21. Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice.
    Mutlu EA, Engen PA, Soberanes S, Urich D, Forsyth CB, Nigdelioglu R, Chiarella SE, Radigan KA, Gonzalez A, Jakate S, Keshavarzian A, Budinger GR, Mutlu GM.
    Part Fibre Toxicol.
    2011 Jun 9
    8:19.
  22. Cap polyposis with protein-losing enteropathy.
    Gallegos M, Lau C, Bradly DP, Blanco L, Keshavarzian A, Jakate SM.
    Gastroenterol Hepatol (N Y).
    2011 Jun
    7(6):415-20
  23. Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease.
    Shannon KM, Keshavarzian A, Mutlu E, Dodiya HB, Daian D, Jaglin JA, Kordower JH.
    Mov Disord.
    2011 Jul 15
    doi: 10.1002/mds.23838
  24. Role of intestinal circadian genes in alcohol-induced gut leakiness.
    Swanson G, Forsyth CB, Tang Y, Shaikh M, Zhang L, Turek FW, Keshavarzian A.
    Alcohol Clin Exp Res.
    2011 Jul
    35(7):1305-14. doi: 10.1111/j.1530-0277.2011.01466.x
  25. The role of oral hygiene in inflammatory bowel disease
    Singhal S, Dian D, Keshavarzian A, Fogg L, Fields JZ, Farhadi A
    Dig Dis Sci
    2011 Jan
    56(1):170-5
  26. Sleep disturbances and inflammatory bowel disease: a potential trigger for disease flare?
    Swanson GR, Burgess HJ, Keshavarzian A
    Expert Rev Clin Immunol
    2011 Jan
    7(1):29-36
  27. Is Moderate Red Wine Consumption Safe in Inactive Inflammatory Bowel Disease?
    Swanson GR, Tieu V, Shaikh M, Forsyth C, Keshavarzian A.
    Digestion.
    2011 Aug 26
    84(3):238-244
  28. Solid-phase microextraction and the human fecal VOC metabolome.
    Dixon E, Clubb C, Pittman S, Ammann L, Rasheed Z, Kazmi N, Keshavarzian A, Gillevet P, Rangwala H, Couch RD.
    PLoS One.
    2011 Apr 8
    6(4):e18471.
  29. Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease.
    Forsyth CB, Shannon KM, Kordower JH, Voigt RM, Shaikh M, Jaglin JA, Estes JD, Dodiya HB, Keshavarzian A.
    PLoS One.
    2011
    6(12):e28032
  30. Histopathology predictors of medically refractory ulcerative colitis
    Melson JE, Giusto D, Kwasny M, Eichenseer P, Jakate S, Keshavarzian A
    Dis Colon Rectum
    2010 Sep
    53(9):1280-6
  31. Apoptosis and inflammation: role of adipokines in inflammatory bowel disease.
    Ponemone V, Keshavarzian A, Brand MI, Saclarides T, Abcarian H, Cabay RJ, Fletcher E, Larsen B, Durstine LJ, Fantuzzi G, Fayad R.
    Clin Transl Gastroenterol. 2010
    2010 Oct 21
    1:e1. doi: 10.1038/ctg.2010.1.
  32. Pattern of alcohol consumption and its effect on gastrointestinal symptoms in inflammatory bowel disease
    Swanson GR, Sedghi S, Farhadi A, Keshavarzian A
    Alcohol
    2010 May
    44(3):223-8
  33. Network-based modeling of the human gut microbiome
    Naqvi A, Rangwala H, Keshavarzian A, Gillevet P
    Chem Biodivers
    2010 May
    7(5):1040-50
  34. Quantitative assessment of the human gut microbiome using multitag pyrosequencing
    Gillevet P, Sikaroodi M, Keshavarzian A, Mutlu EA
    Chem Biodivers
    2010 May
    7(5):1065-75
  35. Starch-entrapped microspheres show a beneficial fermentation profile and decrease in potentially harmful bacteria during in vitro fermentation in faecal microbiota obtained from patients with inflammatory bowel disease
    Rose DJ, Venema K, Keshavarzian A, Hamaker BR
    Br J Nutr
    2010 May
    103(10):1514-24
  36. The Role of Matrix Metalloproteinases in Intestinal Epithelial Wound Healing During Normal and Inflammatory States
    Hayden DM, Forsyth C, Keshavarzian A
    J Surg Res
    2010 Mar 26
  37. Endogenous melatonin profiles in asymptomatic inflammatory bowel disease
    Burgess HJ, Swanson GR, Keshavarzian A
    Scand J Gastroenterol
    2010 Jun
    45(6):759-61
  38. Alcohol stimulates activation of Snail, epidermal growth factor receptor signaling, and biomarkers of epithelial-mesenchymal transition in colon and breast cancer cells
    Forsyth CB, Tang Y, Shaikh M, Zhang L, Keshavarzian A
    Alcohol Clin Exp Res
    2010 Jan
    34(1):19-31
  39. Current Therapeutic Approaches in Inflammatory Bowel Disease
    Sohrabpour AA, Malekzadeh R, Keshavarzian A
    Curr Pharm Des
    2010 Dec 3
  40. Effects of aspirin on gastroduodenal permeability in alcoholics and controls
    Farhadi A, Keshavarzian A, Kwasny MJ, Shaikh M, Fogg L, Lau C, Fields JZ, Forsyth CB
    Alcohol
    2010 Aug
    44(5):447-56
  41. Laparoscopic transgastric esophageal mucosal resection: 4-year minimum follow-up
    Frantzides CT, Carlson MA, Keshavarzian A, Roberts JE
    Am J Surg
    2010 Aug
    200(2):305-7
  42. MicroRNAs: master regulators of ethanol abuse and toxicity?
    Miranda RC, Pietrzykowski AZ, Tang Y, Sathyan P, Mayfield D, Keshavarzian A, Sampson W, Hereld D
    Alcohol Clin Exp Res
    2010 Apr
    34(4):575-87
  43. Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats
    Mutlu E, Keshavarzian A, Engen P, Forsyth CB, Sikaroodi M, Gillevet P
    Alcohol Clin Exp Res
    2009 Oct
    33(10):1836-46
  44. Starch-entrapped microspheres extend in vitro fecal fermentation, increase butyrate production, and influence microbiota pattern
    Rose DJ, Keshavarzian A, Patterson JA, Venkatachalam M, Gillevet P, Hamaker BR
    Mol Nutr Food Res
    2009 May
    53 Suppl 1:S121-30
  45. SIMDOT-AbMe: microphysiologically based simulation tool for quantitative prediction of systemic and local bioavailability of targeted oral delivery formulations
    Haddish-Berhane N, Farhadi A, Nyquist C, Haghighi K, Keshavarzian A
    Drug Metab Dispos
    2009 Mar
    37(3):608-18
  46. Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis
    Forsyth CB, Farhadi A, Jakate SM, Tang Y, Shaikh M, Keshavarzian A
    Alcohol
    2009 Mar
    43(2):163-72
  47. Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats
    Keshavarzian A, Farhadi A, Forsyth CB, Rangan J, Jakate S, Shaikh M, Banan A, Fields JZ
    J Hepatol
    2009 Mar
    50(3):538-47
  48. Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis
    Tang Y, Preuss F, Turek FW, Jakate S, Keshavarzian A
    Sleep Med
    2009 Jun
    10(6):597-603
  49. Oats supplementation prevents alcohol-induced gut leakiness in rats by preventing alcohol-induced oxidative tissue damage
    Tang Y, Forsyth CB, Banan A, Fields JZ, Keshavarzian A
    J Pharmacol Exp Ther
    2009 Jun
    329(3):952-8
  50. Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage
    Tang Y, Forsyth CB, Farhadi A, Rangan J, Jakate S, Shaikh M, Banan A, Fields JZ, Keshavarzian A
    Alcohol Clin Exp Res
    2009 Jul
    33(7):1220-30
  51. Reconsidering the methodology of "stress" research in inflammatory bowel disease
    Keefer L, Keshavarzian A, Mutlu E
    J Crohns Colitis
    2008 Sep
    2(3):193-201
  52. Atopic irritable bowel syndrome: a novel subgroup of irritable bowel syndrome with allergic manifestations
    Tobin MC, Moparty B, Farhadi A, DeMeo MT, Bansal PJ, Keshavarzian A
    Ann Allergy Asthma Immunol
    2008 Jan
    100(1):49-53
  53. Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease
    Tang Y, Banan A, Forsyth CB, Fields JZ, Lau CK, Zhang LJ, Keshavarzian A
    Alcohol Clin Exp Res
    2008 Feb
    32(2):355-64
  54. Adverse effects of chronic circadian desynchronization in animals in a "challenging" environment
    Preuss F, Tang Y, Laposky AD, Arble D, Keshavarzian A, Turek FW
    Am J Physiol Regul Integr Comp Physiol
    2008 Dec
    295(6):R2034-40
  55. Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis
    Farhadi A, Gundlapalli S, Shaikh M, Frantzides C, Harrell L, Kwasny MM, Keshavarzian A
    Liver Int
    2008 Aug
    28(7):1026-33
  56. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium
    Purohit V, Bode JC, Bode C, Brenner DA, Choudhry MA, Hamilton F, Kang YJ, Keshavarzian A, Rao R, Sartor RB, Swanson C, Turner JR
    Alcohol
    2008 Aug
    42(5):349-61
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