Faculty Rank: Associate Professor
Medical or Graduate Education:
Loyola University Chicago Stritch School of Medicine
Rush University Medical Center - Psychiatry
Psychopharmacology and clinical research
Vagus nerve stimulation
Psychotherapy and pharmacological treatments for depression
Below is a list of scientific publications for which this practitioner was either the primary author or a contributor. Citations come from PubMed, a database of biomedical literature, life science journals and online books. PubMed is a service of the US Library of Medicine at the National Institutes of Health. Click on the title of the cited work for more information (this will take you directly to PubMed.gov). Listings go back five years.
A Randomized, Placebo-Controlled, Active-Reference, Double-Blind, Flexible-Dose Study of the Efficacy of Vortioxetine on Cognitive Function in Major Depressive Disorder. Mahableshwarkar AR, Zajecka J, Jacobson W, Chen Y, Keefe RS Neuropsychopharmacology 2015 Feb 17 :. Effect of Cognitive Therapy With Antidepressant Medications vs Antidepressants Alone on the Rate of Recovery in Major Depressive Disorder: A Randomized Clinical Trial. Hollon SD, DeRubeis RJ, Fawcett J, Amsterdam JD, Shelton RC, Zajecka J, Young PR, Gallop R JAMA Psychiatry 2014 Oct 1 71(10):1157-64. Effect of adjunctive L-methylfolate 15 mg among inadequate responders to SSRIs in depressed patients who were stratified by biomarker levels and genotype: results from a randomized clinical trial. Papakostas GI, Shelton RC, Zajecka JM, Bottiglieri T, Roffman J, Cassiello C, Stahl SM, Fava M J Clin Psychiatry 2014 Apr 15 Residual symptoms in major depressive disorder: prevalence, effects, and management. Zajecka J, Kornstein SG, Blier P. J Clin Psychiatry. 2013 2013 Apr 74(4):407-14. doi: 10.4088/JCP.12059ah1. Review. No abstract available. Residual symptoms and relapse: mood, cognitive symptoms, and sleep disturbances. Zajecka JM J Clin Psychiatry 2013 74 Suppl 2:9-13. l-Methylfolate as Adjunctive Therapy for SSRI-Resistant Major Depression: Results of Two Randomized, Double-Blind, Parallel-Sequential Trials. Papakostas GI, Shelton RC, Zajecka JM, Etemad B, Rickels K, Clain A, Baer L, Dalton ED, Sacco GR, Schoenfeld D, Pencina M, Meisner A, Bottiglieri T, Nelson E, Mischoulon D, Alpert JE, Barbee JG, Zisook S, Fava M. Am J Psychiatry. 2012 2012 Dec 1 169(12):1267-74. doi: 10.1176/appi.ajp.2012.11071114. A 12-week, randomized, double-blind, placebo-controlled, sequential parallel comparison trial of ziprasidone as monotherapy for major depressive disorder. Papakostas GI, Vitolo OV, Ishak WW, Rapaport MH, Zajecka JM, Kinrys G, Mischoulon D, Lipkin SH, Hails KA, Abrams J, Ward SG, Meisner A, Schoenfeld DA, Shelton RC, Winokur A, Okasha MS, Bari MA, Fava M. J Clin Psychiatry. 2012 2012 Dec 73(12):1541-7. doi: 10.4088/JCP.12m07670. The use of referenced-EEG (rEEG) in assisting medication selection for the treatment of depression. DeBattista C, Kinrys G, Hoffman D, Goldstein C, Zajecka J, Kocsis J, Teicher M, Potkin S, Preda A, Multani G, Brandt L, Schiller M, Iosifescu D, Fava M. J Psychiatr Res. 2011 2011 Jan 45(1):64-75. doi: 10.1016/j.jpsychires.2010.05.009. Epub 2010 Jul 3. Evidence for the use of l-methylfolate combined with antidepressants in MDD. Fava M, Shelton RC, Zajecka JM. J Clin Psychiatry. 2011 2011 Aug 72(8):e25. doi: 10.4088/JCP.11012tx1c. Psychosocial outcomes in patients with recurrent major depressive disorder during 2 years of maintenance treatment with venlafaxine extended release. Trivedi MH, Dunner DL, Kornstein SG, Thase ME, Zajecka JM, Rothschild AJ, Friedman ES, Shelton RC, Keller MB, Kocsis JH, Gelenberg A. J Affect Disord. 2010 2010 Nov 126(3):420-9. doi: 10.1016/j.jad.2010.04.011. Epub 2010 May 26. Efficacy and safety of agomelatine in the treatment of major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled trial. Zajecka J, Schatzberg A, Stahl S, Shah A, Caputo A, Post A. J Clin Psychopharmacol. 2010 2010 Apr 30(2):135-44. doi: 10.1097/JCP.0b013e3181d420a7. Assessing rates and predictors of tachyphylaxis during the prevention of recurrent episodes of depression with venlafaxine ER for two years (PREVENT) study. Rothschild AJ, Dunlop BW, Dunner DL, Friedman ES, Gelenberg A, Holland P, Kocsis JH, Kornstein SG, Shelton R, Trivedi MH, Zajecka JM, Goldstein C, Thase ME, Pedersen R, Keller MB. Psychopharmacol Bull. 2009 2009 42(3):5-20. Oral divalproex sodium loading for adolescent outpatients with acute mania/hypomania: a report of 2 cases. Zajecka JM, Gutierrez SN. J Clin Psychiatry. 2008 2008 Jun 69(6):1016-8. No abstract available.
To watch a brief video of John M. Zajecka, MD, click the play button at the lower left corner of the video frame below.
(If you cannot play the video, you may need to update to the latest version of Adobe Flash Player.)
When patients come to see me as a clinician — whether it’s through my private practice or doing clinical research — most of those patients come in with a mood disorder — whether that’s major depression or whether it’s bipolar disorder — and they’re either looking for some verification of a diagnosis and/or treatment.
We follow patients for sometimes 10 years doing clinical research where we provide either personalized treatment, or sometimes something very specific — like a vagus nerve stimulator that we helped bring to market by doing our clinical trials. And we’ve seen patients sustain their improvement of their depression for years and years. And so it’s really bringing cutting-edge treatments to the patients and allowing those patients to experience some relief of their depression.