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Specialty:
Board Certification:
Faculty Rank: Professor
Medical or Graduate Education:
University of Illinois College of Medicine at Chicago
Residency:
University of Illinois Medical Center - Surgery
Massachusetts General Hospital - Orthopedic Surgery
Fellowship:
Rush University Medical Center - Adult Reconstructive Surgery
Clinical Expertise:
Hip injuries and disorders
Hip joint replacement
Hip surgery, revision
Knee injuries and disorders
Knee joint replacement
Knee surgery, revision
Research Interests:
Biomaterial compatibility
Below is a list of scientific publications for which this practitioner was either the primary author or a contributor. Citations come from PubMed, a database of biomedical literature, life science journals and online books. PubMed is a service of the US Library of Medicine at the National Institutes of Health. Click on the title of the cited work for more information (this will take you directly to PubMed.gov). Listings go back five years.
Ten-year outcome of serum metal ion levels after primary total hip arthroplasty: a concise follow-up of a previous report*. Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. Asymptomatic prospective and retrospective cohorts with metal-on-metal hip arthroplasty indicate acquired lymphocyte reactivity varies with metal ion levels on a group basis. An Important Contribution to Our Understanding of the Performance of the Current Generation of Metal-on-Metal Hip Replacements: Commentary on an article by A.J. Hart, MA, MD, FRCSG(Orth), et al.: Which Factors Determine the Wear Rate of Large-Diameter Metal-on-Metal Hip Replacements? Multivariate A... Corrosion at the head-neck taper as a cause for adverse local tissue reactions after total hip arthroplasty. Evidence-based understanding of management perils for metal-on-metal hip arthroplasty patients. Successful long-term fixation and progression of osteolysis associated with first-generation cementless acetabular components retrieved post mortem. Large (36 or 40-mm) femoral heads decreased the rate of dislocation after revision total hip arthroplasty. Do Ion Concentrations after Metal-on-Metal Hip Resurfacing Increase Over Time? A Prospective Study. Wear-corrosion synergism in a CoCrMo hip bearing alloy is influenced by proteins. Evaluation and treatment of painful total hip arthroplasties with modular metal taper junctions. Surface damage versus tibial polyethylene insert conformity: a retrieval study. The utility of MARS MRI in patients with metal-on-metal bearings: commentary on an article by Alister J. Hart, MA, MD, FRCSG(Orth), et al.: Pseudotumors in association with well-functioning metal-on-metal hip prostheses. a case-control study using three-dimensional computed tomography and magnetic ... CoCrMo metal-on-metal hip replacements. Commentary: Total disc arthroplasty and the bearing surface debate. Preventing venous thromboembolic disease in patients undergoing elective total hip and knee arthroplasty. American Academy of Orthopaedic Surgeons clinical practice guideline on: preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty. In vivo oxide-induced stress corrosion cracking of Ti-6Al-4V in a neck-stem modular taper: Emergent behavior in a new mechanism of in vivo corrosion. Effect of europium(II) stearate on the mechanical properties and the oxidation resistance of UHMWPE. Early Failure of Metal-on-Metal Artificial Disc Prostheses Associated with Lymphocytic Reaction: Diagnosis and Treatment Experience in 4 Cases Hematologic genetic testing in high-risk patients before knee arthroplasty: a pilot study A multinational assessment of metal-on-metal bearings in hip replacement. AAOS clinical practice guideline: preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty. Preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty. In vivo wear of a squeaky alumina-on-alumina hip prosthesis: a case report. Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity Fracture of a modular femoral neck after total hip arthroplasty: a case report In vitro reactivity to implant metals demonstrates a person-dependent association with both T-cell and B-cell activation Commentary on an article by Stephen S. Tower, MD: "Arthroprosthetic cobaltism: neurological and cardiac manifestations in two patients with metal-on-metal arthroplasty. a case report" Cruciate-retaining TKA using a third-generation system with a four-pegged tibial component: a minimum 10-year followup note Synovial fluid biomarkers for periprosthetic infection Wear mechanisms in metal-on-metal bearings: the importance of tribochemical reaction layers The evidence-based approach in bringing new orthopaedic devices to market Biologic activity of wear particles Role of technology assessment in orthopaedics US bone and joint decade prepares for the future Primary total hip arthroplasty with a porous-coated acetabular component. A concise follow-up, at a minimum of twenty years, of previous reports Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity In vivo severe corrosion and hydrogen embrittlement of retrieved modular body titanium alloy hip-implants Metal-on-metal bearing surfaces Biologic effects of implant debris Analysis of metal ion-induced DNA damage, apoptosis, and necrosis in human (Jurkat) T-cells demonstrates Ni2+ and V3+ are more toxic than other metals: Al3+, Be2+, Co2+, Cr3+, Cu2+, Fe3+, Mo5+, Nb5+, Zr2+ Translational research: Whither the ORS? Modes of wear after semiconstrained total elbow arthroplasty Osteoarthritis of the hip Th1 type lymphocyte reactivity to metals in patients with total hip arthroplasty AOA symposium. Evidence-based medicine, the quality initiative, and P4P: performance or paperwork? Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption Technology assessment and adoption in orthopaedics: lessons learned How has the biologic reaction to wear particles changed with newer bearing surfaces?
To watch a brief video of Jushua J. Jacobs, MD, click the play button at the lower left corner of the video frame below. (If you cannot play the video, you may need to update to the latest version of Adobe Flash Player.)
View Transcript When I worked in a material science laboratory that dealt with medical devices, that’s when I became hooked on orthopedic surgery. Because I saw how important the materials that are used — for example in joint replacement — have such a critical impact on the outcomes of the surgery.
In my area — in adult reconstructive surgery — a patient will come in typically after years and years of pain and disability involving their hip or knee. And then to see them back a few weeks after surgery, where their pain is gone, and because their pain is gone, their activity level is increased. These are some of the most grateful patients that exist in all of medicine — where you really, you can really see the impact you’ve had on their life.
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