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Faculty Rank: Professor
Medical or Graduate Education:
University of Illinois College of Medicine at Chicago
University of Illinois Medical Center - Surgery
Massachusetts General Hospital - Orthopedic Surgery
Rush University Medical Center - Adult Reconstructive Surgery
Hip injuries and disorders
Hip joint replacement
Hip surgery, revision
Knee injuries and disorders
Knee joint replacement
Knee surgery, revision
Below is a list of scientific publications for which this practitioner was either the primary author or a contributor. Citations come from PubMed, a database of biomedical literature, life science journals and online books. PubMed is a service of the US Library of Medicine at the National Institutes of Health. Click on the title of the cited work for more information (this will take you directly to PubMed.gov). Listings go back five years.
Ten-year outcome of serum metal ion levels after primary total hip arthroplasty: a concise follow-up of a previous report*. Levine BR, Hsu AR, Skipor AK, Hallab NJ, Paprosky WG, Galante JO, Jacobs JJ. J Bone Joint Surg Am. 2013 2013 Mar 20 95(6):512-8. doi: 10.2106/JBJS.L.00471. Inhibition of the Wnt-Î²-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. Ma Y, Ren R, Han EQ, Li H, Chen D, Jacobs JJ, Gitelis S, O'Keefe RJ, Konttinen YT, Yin G, Li TF. Biochem Biophys Res Commun. 2013 2013 Jan 3. doi:pii: S0006-291X(12)02478-3. 10.1016/j.bbrc.2012.12.118. [Epub ahead of print] Asymptomatic prospective and retrospective cohorts with metal-on-metal hip arthroplasty indicate acquired lymphocyte reactivity varies with metal ion levels on a group basis. Hallab NJ, Caicedo M, McAllister K, Skipor A, Amstutz H, Jacobs JJ. J Orthop Res. 2013 2013 Feb 31(2):173-82. doi: 10.1002/jor.22214. Epub 2012 Aug 31. An Important Contribution to Our Understanding of the Performance of the Current Generation of Metal-on-Metal Hip Replacements: Commentary on an article by A.J. Hart, MA, MD, FRCSG(Orth), et al.: Which Factors Determine the Wear Rate of Large-Diameter Metal-on-Metal Hip Replacements? Multivariate A... Jacobs JJ, Wimmer MA. J Bone Joint Surg Am. 2013 2013 Apr 17 95(8):e531-2. doi: 10.2106/JBJS.M.00137. No abstract available. Corrosion at the head-neck taper as a cause for adverse local tissue reactions after total hip arthroplasty. Cooper HJ, Della Valle CJ, Berger RA, Tetreault M, Paprosky WG, Sporer SM, Jacobs JJ. J Bone Joint Surg Am. 2012 2012 Sep 19 94(18):1655-61. Evidence-based understanding of management perils for metal-on-metal hip arthroplasty patients. Kwon YM, Jacobs JJ, MacDonald SJ, Potter HG, Fehring TK, Lombardi AV. J Arthroplasty. 2012 2012 Sep 27(8 Suppl):20-5. doi: 10.1016/j.arth.2012.03.029. Epub 2012 May 17. Successful long-term fixation and progression of osteolysis associated with first-generation cementless acetabular components retrieved post mortem. Urban RM, Hall DJ, Della Valle C, Wimmer MA, Jacobs JJ, Galante JO. J Bone Joint Surg Am. 2012 2012 Oct 17 94(20):1877-85. doi: 10.2106/JBJS.J.01507. Large (36 or 40-mm) femoral heads decreased the rate of dislocation after revision total hip arthroplasty. Jacobs JJ. J Bone Joint Surg Am. 2012 2012 Nov 21 94(22):2095. doi: 10.2106/JBJS.9422.ebo546. No abstract available. Do Ion Concentrations after Metal-on-Metal Hip Resurfacing Increase Over Time? A Prospective Study. Amstutz HC, Campbell PA, Dorey FJ, Johnson AJ, Skipor AK, Jacobs JJ. J Arthroplasty. 2012 2012 Nov 1. doi:pii: S0883-5403(12)00568-2. 10.1016/j.arth.2012.07.040. [Epub ahead of print] Wear-corrosion synergism in a CoCrMo hip bearing alloy is influenced by proteins. Mathew MT, Jacobs JJ, Wimmer MA. Clin Orthop Relat Res. 2012 2012 Nov 470(11):3109-17. doi: 10.1007/s11999-012-2563-5. Evaluation and treatment of painful total hip arthroplasties with modular metal taper junctions. Meneghini RM, Hallab NJ, Jacobs JJ. Orthopedics. 2012 2012 May 35(5):386-91. doi: 10.3928/01477447-20120426-03. Surface damage versus tibial polyethylene insert conformity: a retrieval study. Wimmer MA, Laurent MP, Haman JD, Jacobs JJ, Galante JO. Clin Orthop Relat Res. 2012 2012 Jul 470(7):1814-25. doi: 10.1007/s11999-012-2274-y. The utility of MARS MRI in patients with metal-on-metal bearings: commentary on an article by Alister J. Hart, MA, MD, FRCSG(Orth), et al.: Pseudotumors in association with well-functioning metal-on-metal hip prostheses. a case-control study using three-dimensional computed tomography and magnetic ... Jacobs JJ. J Bone Joint Surg Am. 2012 2012 Feb 15 94(4):e26. doi: 10.2106/JBJS.K.01602. No abstract available. CoCrMo metal-on-metal hip replacements. Liao Y, Hoffman E, Wimmer M, Fischer A, Jacobs J, Marks L. Phys Chem Chem Phys. 2012 2012 Dec 12 15(3):746-56. doi: 10.1039/c2cp42968c. Commentary: Total disc arthroplasty and the bearing surface debate. Jacobs JJ, An HS. Spine J. 2012 2012 Aug 12(8):702-4. doi: 10.1016/j.spinee.2011.10.022. No abstract available. Preventing venous thromboembolic disease in patients undergoing elective total hip and knee arthroplasty. Members of 2007 and 2011 AAOS Guideline Development Work Groups on PE/VTED Prophylaxis, Mont M, Jacobs J, Lieberman J, Parvizi J, Lachiewicz P, Johanson N, Watters W. J Bone Joint Surg Am. 2012 2012 Apr 18 94(8):673-4. doi: 10.2106/JBJS.9408edit. No abstract available. American Academy of Orthopaedic Surgeons clinical practice guideline on: preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty. Jacobs JJ, Mont MA, Bozic KJ, Della Valle CJ, Goodman SB, Lewis CG, Yates AC Jr, Boggio LN, Watters WC 3rd, Turkelson CM, Wies JL, Sluka P, Hitchcock K. J Bone Joint Surg Am. 2012 2012 Apr 18 94(8):746-7. doi: 10.2106/JBJS.9408.ebo746. No abstract available. In vivo oxide-induced stress corrosion cracking of Ti-6Al-4V in a neck-stem modular taper: Emergent behavior in a new mechanism of in vivo corrosion. Gilbert JL, Mali S, Urban RM, Silverton CD, Jacobs JJ. J Biomed Mater Res B Appl Biomater. 2011 2011 Nov 24. doi: 10.1002/jbm.b.31943. [Epub ahead of print] Effect of europium(II) stearate on the mechanical properties and the oxidation resistance of UHMWPE. Gallardo LA, Knowlton CB, Kunze J, Jacobs JJ, Wimmer MA, Laurent MP. J Mech Behav Biomed Mater. 2011 2011 Jul 4(5):821-6. doi: 10.1016/j.jmbbm.2010.11.009. Epub 2010 Nov 21. Early Failure of Metal-on-Metal Artificial Disc Prostheses Associated with Lymphocytic Reaction: Diagnosis and Treatment Experience in 4 Cases Guyer RD, Shellock J, Maclennan B, Hanscom D, Knight RQ, McCombe P, Jacobs JJ, Urban RM, Bradford D, Ohnmeiss DD Spine (Phila Pa 1976) 2011 Jan 19 Hematologic genetic testing in high-risk patients before knee arthroplasty: a pilot study Bedair H, Berli M, Gezer S, Jacobs JJ, Della Valle CJ Clin Orthop Relat Res 2011 Jan 469(1):131-7 A multinational assessment of metal-on-metal bearings in hip replacement. Graves SE, Rothwell A, Tucker K, Jacobs JJ, Sedrakyan A. J Bone Joint Surg Am. 2011 2011 Dec 21 93 Suppl 3:43-7. doi: 10.2106/JBJS.K.01220. AAOS clinical practice guideline: preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty. Mont MA, Jacobs JJ. J Am Acad Orthop Surg. 2011 2011 Dec 19(12):777-8. No abstract available. Preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty. Mont MA, Jacobs JJ, Boggio LN, Bozic KJ, Della Valle CJ, Goodman SB, Lewis CG, Yates AJ Jr, Watters WC 3rd, Turkelson CM, Wies JL, Donnelly P, Patel N, Sluka P; AAOS. J Am Acad Orthop Surg. 2011 2011 Dec 19(12):768-76. In vivo wear of a squeaky alumina-on-alumina hip prosthesis: a case report. Laurent MP, Pourzal R, Fischer A, Bertin KC, Jacobs JJ, Wimmer MA. J Bone Joint Surg Am. 2011 2011 Apr 6 93(7):e27. doi: 10.2106/JBJS.I.00930. No abstract available. Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity Caicedo MS, Pennekamp PH, McAllister K, Jacobs JJ, Hallab NJ J Biomed Mater Res A 2010 Jun 15 93(4):1312-21 Fracture of a modular femoral neck after total hip arthroplasty: a case report Wright G, Sporer S, Urban R, Jacobs J J Bone Joint Surg Am 2010 Jun 92(6):1518-21 In vitro reactivity to implant metals demonstrates a person-dependent association with both T-cell and B-cell activation Hallab NJ, Caicedo M, Epstein R, McAllister K, Jacobs JJ J Biomed Mater Res A 2010 Feb 92(2):667-82 Commentary on an article by Stephen S. Tower, MD: "Arthroprosthetic cobaltism: neurological and cardiac manifestations in two patients with metal-on-metal arthroplasty. a case report" Jacobs JJ J Bone Joint Surg Am 2010 Dec 1 92(17):e35 Cruciate-retaining TKA using a third-generation system with a four-pegged tibial component: a minimum 10-year followup note Schwartz AJ, Della Valle CJ, Rosenberg AG, Jacobs JJ, Berger RA, Galante JO Clin Orthop Relat Res 2010 Aug 468(8):2160-7 Synovial fluid biomarkers for periprosthetic infection Deirmengian C, Hallab N, Tarabishy A, Della Valle C, Jacobs JJ, Lonner J, Booth RE Jr Clin Orthop Relat Res 2010 Aug 468(8):2017-23 Wear mechanisms in metal-on-metal bearings: the importance of tribochemical reaction layers Wimmer MA, Fischer A, Büscher R, Pourzal R, Sprecher C, Hauert R, Jacobs JJ J Orthop Res 2010 Apr 28(4):436-43 The evidence-based approach in bringing new orthopaedic devices to market Schemitsch EH, Bhandari M, Boden SD, Bourne RB, Bozic KJ, Jacobs JJ, Zdero R J Bone Joint Surg Am 2010 Apr 92(4):1030-7 Biologic activity of wear particles Catelas I, Jacobs JJ Instr Course Lect 2010 59:3-16 Role of technology assessment in orthopaedics Turkelson C, Jacobs JJ Clin Orthop Relat Res 2009 Oct 467(10):2570-6 US bone and joint decade prepares for the future Jacobs JJ, King T Arthritis Rheum 2009 Nov 15 61(11):1470-1 Primary total hip arthroplasty with a porous-coated acetabular component. A concise follow-up, at a minimum of twenty years, of previous reports Della Valle CJ, Mesko NW, Quigley L, Rosenberg AG, Jacobs JJ, Galante JO J Bone Joint Surg Am 2009 May 91(5):1130-5 Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity Caicedo MS, Desai R, McAllister K, Reddy A, Jacobs JJ, Hallab NJ J Orthop Res 2009 Jul 27(7):847-54 In vivo severe corrosion and hydrogen embrittlement of retrieved modular body titanium alloy hip-implants Rodrigues DC, Urban RM, Jacobs JJ, Gilbert JL J Biomed Mater Res B Appl Biomater 2009 Jan 88(1):206-19 Metal-on-metal bearing surfaces Jacobs JJ, Urban RM, Hallab NJ, Skipor AK, Fischer A, Wimmer MA J Am Acad Orthop Surg 2009 Feb 17(2):69-76 Biologic effects of implant debris Hallab NJ, Jacobs JJ Bull NYU Hosp Jt Dis 2009 67(2):182-8 Analysis of metal ion-induced DNA damage, apoptosis, and necrosis in human (Jurkat) T-cells demonstrates Ni2+ and V3+ are more toxic than other metals: Al3+, Be2+, Co2+, Cr3+, Cu2+, Fe3+, Mo5+, Nb5+, Zr2+ Caicedo M, Jacobs JJ, Reddy A, Hallab NJ J Biomed Mater Res A 2008 Sep 15 86(4):905-13 Translational research: Whither the ORS? Jacobs JJ J Orthop Res 2008 May 26(5):737-40 Modes of wear after semiconstrained total elbow arthroplasty Goldberg SH, Urban RM, Jacobs JJ, King GJ, O'Driscoll SW, Cohen MS J Bone Joint Surg Am 2008 Mar 90(3):609-19 Osteoarthritis of the hip Beaty J, Jacobs JJ, Berry D N Engl J Med 2008 Jan 31 358(5):534; author reply 534-5 Th1 type lymphocyte reactivity to metals in patients with total hip arthroplasty Hallab NJ, Caicedo M, Finnegan A, Jacobs JJ J Orthop Surg Res 2008 Feb 13 3:6 AOA symposium. Evidence-based medicine, the quality initiative, and P4P: performance or paperwork? Henley MB, Turkelson C, Jacobs JJ, Haralson RH J Bone Joint Surg Am 2008 Dec 90(12):2781-90 Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption Tunyogi-Csapo M, Kis-Toth K, Radacs M, Farkas B, Jacobs JJ, Finnegan A, Mikecz K, Glant TT Arthritis Rheum 2008 Aug 58(8):2397-408 Technology assessment and adoption in orthopaedics: lessons learned Bozic KJ, Jacobs JJ J Bone Joint Surg Am 2008 Apr 90(4):689-90 How has the biologic reaction to wear particles changed with newer bearing surfaces? Jacobs JJ, Campbell PA, T Konttinen Y; Implant Wear Symposium 2007 Biologic Work Group J Am Acad Orthop Surg 2008 16 Suppl 1:S49-55
To watch a brief video of Jushua J. Jacobs, MD, click the play button at the lower left corner of the video frame below.
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When I worked in a material science laboratory that dealt with medical devices, that’s when I became hooked on orthopedic surgery. Because I saw how important the materials that are used — for example in joint replacement — have such a critical impact on the outcomes of the surgery.
In my area — in adult reconstructive surgery — a patient will come in typically after years and years of pain and disability involving their hip or knee. And then to see them back a few weeks after surgery, where their pain is gone, and because their pain is gone, their activity level is increased. These are some of the most grateful patients that exist in all of medicine — where you really, you can really see the impact you’ve had on their life.