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Faculty Rank: Professor
Medical or Graduate Education:
Creighton University School of Medicine
University of Illinois Medical Center - Pediatrics
UCLA Medical Center - Hematology/Oncology
Blood disorders, noncancerous
Bone marrow aspiration and biopsy
Coagulation and thrombosis
Clotting disorders in children
Factor V Leiden
Prothrombin gene mutation
von Willebrand Disease
Below is a list of scientific publications for which this practitioner was either the primary author or a contributor. Citations come from PubMed, a database of biomedical literature, life science journals and online books. PubMed is a service of the US Library of Medicine at the National Institutes of Health. Click on the title of the cited work for more information (this will take you directly to PubMed.gov). Listings go back five years.
A preventive approach to the management of severe hemophilia A. Valentino LA. Clin Adv Hematol Oncol. 2012 2012 Mar 10(3):185-6. No abstract available. Management of joint bleeding in hemophilia. Simpson ML, Valentino LA. Expert Rev Hematol. 2012 2012 Aug 5(4):459-68. Recombinant FIXFc: a novel therapy for the royal disease? Valentino LA. Expert Opin Biol Ther. 2011 Oct 11(10):1361-8 Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients. Shapiro AD, Ragni MV, Valentino LA, Key NS, Josephson NC, Powell JS, Cheng G, Thompson AR, Goyal J, Tubridy KL, Peters RT, Dumont JA, Euwart D, Li L, Hallén B, Gozzi P, Bitonti AJ, Jiang H, Luk A, Pierce GF. Blood. 2011 Nov 22 Venous access in the management of hemophilia Valentino LA, Kawji M, Grygotis M Blood Rev 2011 Jan 25(1):11-5 Assessment of blood-induced arthritis causes friction Valentino LA, Hakobyan N Haemophilia 2011 Jan 17(1):e242-3; doi: 10.1111/j.1365-2516.2010.02374.x. Blood-induced joint disease: the pathophysiology of hemophilic arthropathy Valentino LA J Thromb Haemost 2010 Sep 8(9):1895-902; doi: 10.1111/j.1538-7836.2010.03962.x Control of disseminated intravascular coagulation in Klippel-Trenaunay-Weber syndrome using enoxaparin and recombinant activated factor VIIa: a case report Beier UH, Schmidt ML, Hast H, Kecskes S, Valentino LA J Med Case Reports 2010 Mar 19 4:92 Assessing the benefits of FEIBA prophylaxis in haemophilia patients with inhibitors Valentino LA Haemophilia 2010 Mar 16(2):263-71 Novel drugs to treat hemophilia Valentino LA, Ismael Y, Grygotis M Expert Opin Emerg Drugs 2010 Dec 15(4):597-613 The Fourth Annual Meeting of the International Network for Pediatric Hemophilia: Current Challenges and Recommendations in the Clinical Care of Children with Hemophilia. Ljung R, van den Berg M, Valentino LA, Manco-Johnson M. Transfus Med Hemother. 2010 37(4):209-212 Experience with a third generation recombinant factor VIII concentrate (Advate) for immune tolerance induction in patients with haemophilia A Valentino LA, Recht M, Dipaola J, Shapiro AD, Pipe SW, Ewing N, Urgo J, Bullock T, Simmons M, Deguzman C Haemophilia 2009 May 15(3):718-26 The benefits of prophylactic treatment with APCC in patients with haemophilia and high-titre inhibitors: a retrospective case series Valentino LA Haemophilia 2009 May 15(3):733-42 The application of bypassing-agent prophylaxis in haemophilia A patients with inhibitors: a meeting report Valentino LA, Carcao M, Mathew P, Leissinger CA, Berntorp E, Blanchette V, Escuriola-Ettingshausen C, Ewenstein B, Ewing N, Gringeri A, Hoots WK, Negrier C Haemophilia 2009 Jul 15(4):959-65 Prevention of haemarthrosis in a murine model of acute joint bleeding Valentino LA, Hakobyan N, Kazarian T, Sorensen BB, Tranholm M Haemophilia 2009 Jan 15(1):314-9 Controversies regarding the prophylactic management of adults with severe haemophilia A Valentino LA Haemophilia 2009 Dec 15 Suppl 2:5-18, quiz 19-22 Recombinant activated factor VII as a temporary reversal agent for warfarin anticoagulation: a cautionary report on an off-label application. Kalainov DM, Valentino LA. Am J Orthop (Belle Mead NJ). 2008 Nov 37(11):572-4 Experimental haemophilic arthropathy in a mouse model of a massive haemarthrosis: gross, radiological and histological changes Hakobyan N, Enockson C, Cole AA, Sumner DR, Valentino LA Haemophilia 2008 Jul 14(4):804-9 Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX. Sun J, Hakobyan N, Valentino LA, Feldman BL, Samulski RJ, Monahan PE. Blood. 2008 Dec 1 112(12):4532-41 Blood-induced joint disease: the confluence of dysregulated oncogenes, inflammatory signals, and angiogenic cues Valentino LA, Hakobyan N, Enockson C Semin Hematol 2008 Apr 45(2 Suppl 1):S50-7
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Investigating people who have blood problems is a really interesting and rewarding area of medicine. It’s very detective-like. So there’s people who come in with particular problems that nobody’s been able to solve before. And we’re able to do that through a very sophisticated laboratory approach, as well as our comprehensive team of health care providers who can evaluate these patients on an ongoing basis.
Hemophilia is frequently diagnosed in young children, especially when it’s severe disease. They’ll present with either bruising or with joint bleeding. People who have Von Willebrand disease, they’ll present with bruising or nose bleeding. And then women can have heavy periods as well. Through the use of specialized medications that both enhance blood clotting — either the replacement of Von Willebrand factor or the defective blood clotting protein in hemophilia — we can ameliorate many of those symptoms.