Roy A.E. Bakay, MD

Below is a list of scientific publications for which this practitioner was either the primary author or a contributor. Citations come from PubMed, a database of biomedical literature, life science journals and online books. PubMed is a service of the US Library of Medicine at the National Institutes of Health. Click on the title of the cited work for more information (this will take you directly to PubMed.gov). Listings go back five years.

1. Displacement of a Deep Brain Stimulator Lead During Placement of an Additional Ipsilateral Lead.
   Falowski S, Ghods AJ, Bakay RA.
   Neuromodulation. 2012
   2012 Sep 4. doi: 10.1111/j.1525-1403.2012.00500.x. [Epub ahead of print]
   
2. Effect of intraoperative subthalamic nucleus DBS on human single-unit activity in the ipsilateral and contralateral subthalamic nucleus.
   Toleikis JR, Metman LV, Pilitsis JG, Barborica A, Toleikis SC, Bakay RA.
   J Neurosurg. 2012
   2012 May;116(5):1134-43. Epub 2012 Feb 17.
   116(5):1134
   
3. Intraoperative x-ray to measure distance between DBS leads: A reliability study.
   Verhagen Metman L, Pilitsis JG, Stebbins GT, Bot M, Bakay RA.
   Mov Disord. 2012
   2012 Jul
   27(8):1056-9. doi: 10.1002/mds.25056. Epub 2012 Jun 12.
   
4. Deep brain stimulation and hemorrhage.
   Bakay RA, Vannemreddy PS.
   J Neurosurg. 2012
   2012 Apr
   116(4):929-30; author reply 930-2. doi: 10.3171/2011.10.JNS111739. Epub 2012 Feb 3. No abstract available.
   
5. Deep brain stimulation and seizures.
   Bakay RA, Vannemreddy PS.
   J Neurosurg. 2012
   2012 Apr
   116(4):926; author reply 926-7. doi: 10.3171/2011.8.JNS111461. Epub 2012 Jan 13. No abstract available.
   
6. An evaluation of hardware and surgical complications with deep brain stimulation based on diagnosis and lead location.
   Falowski S, Ooi YC, Smith A, Verhargen Metman L, Bakay RA.
   Stereotact Funct Neurosurg. 2012
   2012
   90(3):173-80. doi: 10.1159/000338254. Epub 2012 Jun 5.
   
7. Neural Prosthesis: Concept and Progress.
   Bakay RA, Vannemreddy PS.
   World Neurosurg.
   2011 Nov 1
   
8. Perspectives on "fusion image-based programming after subthalamic nucleus deep brain stimulation"
   Bakay RA, Falowski S.
   World Neurosurg.
   2011 Mar-Apr
   75(3-4):436-7
   
9. Intrastriatal transplantation of microcarrier-bound human retinal pigment epithelial cells versus sham surgery in patients with advanced Parkinson's disease: a double-blind, randomised, controlled trial.
   Gross RE, Watts RL, Hauser RA, Bakay RA, Reichmann H, von Kummer R, Ondo WG, Reissig E, Eisner W, Steiner-Schulze H, Siedentop H, Fichte K, Hong W, Cornfeldt M, Beebe K, Sandbrink R; Spheramine Investigational Group.
   Lancet Neurol.
   2011 Jun
   10(6):509-19
   
10. Dyskinesias do not develop after chronic intermittent levodopa therapy in clinically hemiparkinsonian rhesus monkeys
    Lieu CA, Deogaonkar M, Bakay RA, Subramanian T
    Parkinsonism Relat Disord
    2011 Jan
    17(1):34-9
    
11. Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues
    Bronstein JM, Tagliati M, Alterman RL, Lozano AM, Volkmann J, Stefani A, Horak FB, Okun MS, Foote KD, Krack P, Pahwa R, Henderson JM, Hariz MI, Bakay RA, Rezai A, Marks WJ Jr, Moro E, Vitek JL, Weaver FM, Gross RE, Delong MR
    Arch Neurol
    2011 Feb
    68(2):165
    
12. Frameless deep brain stimulation using intraoperative O-arm technology.
    Smith AP, Bakay RA.
    J Neurosurg.
    2011 Aug
    115(2):301-9
    
13. Effects of five years of chronic STN stimulation on muscle strength and movement speed
    Sturman MM, Vaillancourt DE, Metman LV, Bakay RA, Corcos DM
    Exp Brain Res
    2010 Sep
    205(4):435-43
    
14. Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy
    Fisher R, Salanova V, Witt T, Worth R, Henry T, Gross R, Oommen K, Osorio I, Nazzaro J, Labar D, Kaplitt M, Sperling M, Sandok E, Neal J, Handforth A, Stern J, DeSalles A, Chung S, Shetter A, Bergen D, Bakay R, Henderson J, French J, Baltuch G, Rosenfeld W, Youkilis A, Marks W, Garcia P, Barbaro N, Fountain N, Bazil C, Goodman R, McKhann G, Babu Krishnamurthy K, Papavassiliou S, Epstein C, Pollard J, Tonder L, Grebin J, Coffey R, Graves N; SANTE Study Group
    Epilepsia
    2010 May
    51(5):899-908
    
15. Safety of magnetic resonance imaging of deep brain stimulator systems: a serial imaging and clinical retrospective study
    Chhabra V, Sung E, Mewes K, Bakay RA, Abosch A, Gross RE
    J Neurosurg
    2010 Mar
    112(3):497-502
    
16. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial
    Marks WJ Jr, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis N, Vitek J, Stacy M, Turner D, Verhagen L, Bakay R, Watts R, Guthrie B, Jankovic J, Simpson R, Tagliati M, Alterman R, Stern M, Baltuch G, Starr PA, Larson PS, Ostrem JL, Nutt J, Kieburtz K, Kordower JH, Olanow CW
    Lancet Neurol
    2010 Dec
    9(12):1164-72
    
17. Standard guidelines for publication of deep brain stimulation studies in Parkinson's disease (Guide4DBS-PD)
    Vitek JL, Lyons KE, Bakay R, Benabid AL, Deuschl G, Hallett M, Kurlan R, Pancrazio JJ, Rezai A, Walter BL, Lang AE
    Mov Disord
    2010 Aug 15
    25(11):1530-7
    
18. Somatotopic organization in the internal segment of the globus pallidus in Parkinson's disease
    Baker KB, Lee JY, Mavinkurve G, Russo GS, Walter B, DeLong MR, Bakay RA, Vitek JL
    Exp Neurol
    2010 Apr
    222(2):219-25
    
19. Neurotrophic factor therapy for Parkinson's disease
    Rangasamy SB, Soderstrom K, Bakay RA, Kordower JH
    Prog Brain Res
    2010
    184:237-64
    
20. Stimulation-induced parkinsonism after posteroventral deep brain stimulation of the globus pallidus internus for craniocervical dystonia
    Zauber SE, Watson N, Comella CL, Bakay RA, Metman LV
    J Neurosurg
    2009 Feb
    110(2):229-33
    
21. Survival of mossy cells of the hippocampal dentate gyrus in humans with mesial temporal lobe epilepsy
    Seress L, Abrahám H, Horváth Z, Dóczi T, Janszky J, Klemm J, Byrne R, Bakay RA
    J Neurosurg
    2009 Dec
    111(6):1237-47
    
22. Deep brain stimulation for schizophrenia
    Bakay RA
    Stereotact Funct Neurosurg
    2009
    87(4):266
    
23. Factors involved in long-term efficacy of deep brain stimulation of the thalamus for essential tremor
    Pilitsis JG, Metman LV, Toleikis JR, Hughes LE, Sani SB, Bakay RA
    J Neurosurg
    2008 Oct
    109(4):640-6
    
24. Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum
    Herzog CD, Dass B, Gasmi M, Bakay R, Stansell JE, Tuszynski M, Bankiewicz K, Chen EY, Chu Y, Bishop K, Kordower JH, Bartus RT
    Mol Ther
    2008 Oct
    16(10):1737-44
    
25. Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial
    Marks WJ Jr, Ostrem JL, Verhagen L, Starr PA, Larson PS, Bakay RA, Taylor R, Cahn-Weiner DA, Stoessl AJ, Olanow CW, Bartus RT
    Lancet Neurol
    2008 May
    7(5):400-8
    
26. Postmortem study of deep brain stimulation of the anterior thalamus: case report
    Pilitsis JG, Chu Y, Kordower J, Bergen DC, Cochran EJ, Bakay RA
    Neurosurgery
    2008 Feb
    62(2):E530-2; discussion E532
    
27. Effect of short and long term STN stimulation periods on parkinsonian signs
    Sturman MM, Vaillancourt DE, Shapiro MB, Metman LV, Bakay RA, Corcos DM
    Mov Disord
    2008 Apr 30
    23(6):866-74
    
28. Cortical stimulation for the rehabilitation of patients with hemiparetic stroke: a multicenter feasibility study of safety and efficacy
    Levy R, Ruland S, Weinand M, Lowry D, Dafer R, Bakay R
    J Neurosurg
    2008 Apr
    108(4):707-14
    
29. Therapeutic potentials of human embryonic stem cells in Parkinson's disease
    Newman MB, Bakay RA
    Neurotherapeutics
    2008 Apr
    5(2):237-51
    
30. Ventral intermediate thalamic stimulation in complex tremor syndromes.
    Diederich NJ, Verhagen Metman L, Bakay RA, Alesch F.
    Stereotact Funct Neurosurg.
    2008
    86(3):167-72
    

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• What I really have passion for, and what I really work for is functional neurosurgery — that is changing the symptoms of the disease. So if one has epilepsy and uncontrolled seizures, we can intervene with surgery and decrease or even eliminate the seizures. If we have a child who has dystonia — pretzel-like cramping of the muscles — we can unwrap the muscles, relax them — and have the child come out running, jumping and playing as normal — through deep brain stimulation.

  Deep brain stimulation is implanting an electrode in the brain — in the right spot, in the right patient, the right disease — and allowing that stimulator to interfere with the abnormal activity so that the normal activity comes out, and that the behavior improves. The ability of the deep brain stimulator to change the way in which the brain is functioning is remarkable. It’s being used for all types of diseases that we never thought we’d be able to treat before.